Not stop taking Plavix unless told to do so by their healthcare professional. Clopidogrel works by blocking platelets from sticking together and prevents them from forming harmful clots. The following regression model was derived for predicting number of days to R-to-B PRU where PI(1) represents platelet percentage inhibition on Washout Day 1. Bronchoscopy is most commonly performed using a flexible bronchoscope. Talk with your doctor and family members or friends about deciding to join a study. If Plavix (clopidogrel) is stopped, your doctor will tell you when to start taking Plavix (clopidogrel) again after your surgery or procedure. 2012 Jun 19;59(25):2338-43. doi: 10.1016/j.jacc.2012.02.042. History (within the last 5 years) or presence of gastric ulcers. [ Time Frame: up to 12 days after last dose ], Day at Which 50%, 75%, and 90% of Subjects Returned to Baseline Platelet Function Based on Secondary Definition of Return to Baseline Using the Primary Population. A multi-vitamin is ok. • Wear a two piece garment pants should have no metal on them. Specializes in Long term care; med-surg; critical care. They are kept on a heparin drip while the placid works its way out of their system and the the heparin is generally stopped a few hours prior to the procedure since it has a short half life. At the discretion of the physician, aspirin therapy can be continued before, during and after the procedure* Start Tirofiban 24-48 hours after the last clopidogrel dose Dosing: o No bolus needed o CrCl ≥ 30 ml/min: 0.1 mcg/kg/min, stop infusion 4 … For general information, Learn About Clinical Studies. Recovery of platelet function after discontinuation of prasugrel or clopidogrel maintenance dosing in aspirin-treated patients with stable coronary disease: the recovery trial. Platelets. Plavix It's the time needed to allow Plavix that the patient has taken to decrease to a certain level. However, for patients subsequently referred for CABG, a minimum washout period of 5 days should be observed to minimize perioperative bleedin … It is also used together with aspirin in heart attacks and following the placement of a coronary artery stent. The antiplatelet effect of higher loading and maintenance dose regimens of clopidogrel: the PRINC (Plavix Response in Coronary Intervention) trial. Plavix cost, plavix and aspirin 325, pletal and plavix. Typically, I've really only heard the term used by anesthesia providers discussing volatile anesthetics. A 5-day “Plavix washout” for so many patients creates severe logistical problems. After a 1-day to 14-day screening period, subjects will receive active treatment with either prasugrel or clopidogrel for 7 days. Plavix - Plavix generic without prescription, Plavix loading dose before pci, Plavix price in australia. Other drugs may interact with eptifibatide, including prescription and over-the-counter medicines, vitamins, and herbal products. Just started after being on clopidogrel for 5 years Am tired washed out and sleep all the time No obvious bleeding ... View answer. Our members represent more than 60 professional nursing specialties. Plavix should be cleared from your system in about 33 hours. Plavix use after stent placement, should i take plavix and aspirin at the same time, generic plavix may 2012, plavix brand name. We have patient's admitted to step down for plavix washout that are high risk for thromboembolic event. Treatment A consisted of 300 mg clopidogrel on day 1 and 75 mg clopidogrel on day 2. why are some people poor metabolizers for Plavix? This systematic review of nine studies concludes that delaying hip fracture surgery for Plavix washout did not decrease bleeding and led to … Plavix has been evaluated for safety in more than 54,000 patients, including over 21,000 patients treated for one year or more. If a subject has not missed more than 1 dose of study medication and is unable to attend Visit 3 (Washout Day 1) the day after the 7th day of study medication, the subject may take up to an additional 3 days of study medication and proceed to Visit 3 the day after the last dose. Plan Your Ride Select Ride Date. Gladding P, Webster M, Zeng I, et al. Not all possible interactions are listed in this medication guide. Approved methods of birth control are oral, path, injectable or implantable hormonal contraception, intrauterine device, diaphragm plus spermicide, or female condom plus spermicide. View. Please remove one or more studies before adding more. ... After a washout period, subjects were crossed over to the alternate treatment. Women of childbearing potential with a negative serum pregnancy test at screening who are not breast feeding, do not plan to become pregnant during the study, and agree to use an approved method of birth control during the study. Study record managers: refer to the Data Element Definitions if submitting registration or results information. Despite increased risk of thrombosis, guidelines recommend discontinuing thienopyridines 5 to 7 days prior … We hold Plavix, Coumadin, DTI's and XAI's for elective surgery. I've just never heard the term. This is day 12 since I stopped and I'm still feeling the effects (light-headed, dizzy). Plavix fda a washout period, subjects were crossed over to the alternate treatment. Abstinence, partner's use of condoms, and partner's vasectomy are NOT acceptable methods of contraception. In combination with aspirin, the ADP receptor antagonist clopidogrel is used widespread for this purpose; however, platelet reactivity after clopidogrel differs substantially between patients and high on-treatment platelet reactivity (HTPR) persists in a substantial proportion of cases. Pantangan Makanan Bagi Penderita Penyakit Kencing nanah (Gonore). The ability of dialysis to remove a toxin is based on: Molecular weight (size) Protein binding (the more binding present, the harder it is to remove) Volume of distribution ( the higher the harder it is to remove) Water solubility (the more fat soluble and less water soluble a drug, the harder it is to… warfarin • Less data is available for pts on Several large clinical trials have demonstrated improved risk reduction by dual antiplatelet therapy with aspirin and clopidogrel (Plavix). And this is data which is available from the data that was presented to the FDA and it is in the public domain. The clinically important adverse reactions observed in trials comparing Plavix plus aspirin to placebo plus aspirin and trials comparing Plavix alone to … Has 15 years experience. Absolutely correct. Our mission is to Empower, Unite, and Advance every nurse, student, and educator. Patients who had received clopidogrel had a significantly lower incidence of composite endpoints than those who had not. Answered by : ... A neurologist put me on clopidogrel a few weeks ago when he wasn t convinced I didn t have a mini stroke, even after MRI didn t show one. It may be used if … Splitting hairs, but drugs don't "wash out", they have half lives. [ Time Frame: up to 12 days after last dose ], Day at Which 50%, 75%, and 90% of Subjects Returned to Baseline Platelet Function Based on the Secondary Definition of Return to Baseline Using the Responder Population. Do not wear any jewelry to your appointment. We just call it "hold" or "suspend" or "dc" med. So what I am trying to get a sense is… From the clinical trial. It is taken by mouth. Treatment B consisted of a … Prasugrel/Clopidogrel Maintenance Dose Washout Study. Patients with a variant allele of CYP2C19 are 1. Following Visit 3, platelet function testing was performed during each visit of the Washout Period until the subject met the following exit criteria: (Baseline PRU-PRU) less than or equal to 60 units and (Baseline PRU-PRU)/(Baseline PRU) less than or equal to 20%. And therein lies the distinction. Following Visit 3, platelet function testing was performed during each visit of the Washout Period until the subject met the following exit criteria: (Baseline PRU-PRU) less than or equal to 60 units and (Baseline PRU-PRU)/(Baseline PRU) less than or equal to 20%. Gladding P, Webster M, Zeng I, et al. Washout day 7 was the day at which the proportion of prasugrel-treated patients who had returned to baseline reactivity was closest to the proportion attained by the clopidogrel-treated group at washout day 5 (22 [78%] vs. 22 patients [85%], respectively). It discourages the formation of blood clots, which helps prevent heart attacks and strokes caused by clots. RangerJoe: Had single bypass 1996. Plavix should be cleared from your system in about 33 hours. Ticlopidine (Ticlid®) what kind of drug? There were two treatment phases during which cats received either Plavix or generic clopidogrel at a dosage of 18.75 mg PO q24h for 7 days with a 2 week washout between phases. All participants received loading and maintenance doses of both drugs, in a crossover manner, separated by a 2-week washout period. Decreased active metabolite exposure and increased platelet aggregation were observed in the poor metabolizers compared to the other groups. Prior history of acute coronary syndrome (>/= 30 days before screening) including unstable angina or acute myocardial infarction (ST elevation MI [STEMI] or non-ST elevation MI [NSTEMI]), not currently prescribed or currently on thienopyridine therapy; Previous coronary revascularization including percutaneous transluminal coronary angioplasty (PTCA), stent, or coronary artery bypass grafting (CABG) coronary artery disease (>/= 50% obstruction) in at least one coronary vessel after angiography. Choosing to participate in a study is an important personal decision. However, in certain situations, such as if there's a lot of bleeding in your lungs or a large object is stuck in your airway, a rigid bronchoscope may be needed. Clopidogrel, sold under the trade name Plavix among others, is an antiplatelet medication used to reduce the risk of heart disease and stroke in those at high risk. Since 1997, allnurses is trusted by nurses around the globe. New Orleans, La., April 5, 2011 — Takeda Pharmaceuticals North America, Inc. (Takeda) announced the presentation of new study results, which evaluated the potential inhibitory effects of certain proton pump inhibitors (PPIs) on Plavix (clopidogrel bisulfate). In terms of washing out, yes. For example: Coumadin, Plavix, Heparin • Do not take anti-inflammatory products 7 days before the biopsy. Transition of Anticoagulants 2019 Van Hellerslia, PharmD, BCPS, CACP, Clinical Assistant Professor of Pharmacy Practice, Temple University School of Pharmacy, Philadelphia, PA COVID-19 is an emerging, rapidly evolving situation. After a washout period of 7 days, they will receive a unique dose of 75mg (a tablet) of Clopidogrel by oral route between 8:00 and 9:00am too. Wash out. Subjects with a history or evidence of congestive heart failure (New York Heart Association [NYHA] Class III or above) within 6 months prior to screening. (Clinical Trial), Triple (Participant, Investigator, Outcomes Assessor), Recovery of Platelet Function Following Discontinuation of Prasugrel or Clopidogrel Maintenance Dosing in Aspirin-Treated Subjects With Stable Coronary Disease, 18 Years to 74 Years (Adult, Older Adult), La Jolla, California, United States, 92037, University of Florida Health Science Center Shands Jacksonville, Jacksonville, Florida, United States, 32209, Rapid City, South Dakota, United States, 57701, The Time to Return to Baseline Platelet Function as Assessed by P2Y12 Reaction Units (PRU) Using the Accumetrics VerifyNOW P2Y12 Device Based on the Primary Definition of Return to Baseline [ Time Frame: up to 12 days after last dose ], The Time to Return to Baseline Platelet Function as Assessed by P2Y12 Reaction Units (PRU) Using the Accumetrics VerifyNOW P2Y12 Device Based on the Secondary Definition of Return to Baseline. Plavix is given to reduce the risk of heart attack, unstable angina, stroke, ... After a washout period, subjects were crossed over to the alternate treatment. Subjects with a history of refractory ventricular arrhythmias. It provides a reasonable starting point for most patients but the clinical background of each patient must be considered before applying the guidance; if … Plavix is given to reduce the risk of heart attack, unstable angina, stroke, and cardiovascular death in patients with cardiovascular disease. Information provided by (Responsible Party): The primary objective of the study is to describe the cumulative proportion of subjects who return to baseline platelet P2Y12 receptor function over time (up to 12 days post last maintenance dose) following discontinuation of prasugrel 10 mg daily x 7 days assessed by Accumetrics VerifyNow P2Y12 reaction units (PRU) and described by Kaplan Meier curves. [ Time Frame: up to 12 days after last dose ], Day at Which 50%, 75%, and 90% of Subjects Returned to Baseline Platelet Function Based on Primary Definition of Return to Baseline Using the Primary Population. It involves changing the concentration gradient of the gas from the blood to the alveoli, and that's for another thread, but the point is that the oxygen does the "washing". This systematic review of nine studies concludes that delaying hip fracture surgery for Plavix washout did not decrease bleeding and led to … The recommendation of a 5-day washout period for clopidogrel should be reconsidered to be on par with current clinical practice. 1-612-816-8773. Common procedures and associated bleeding risks • Low and high bleeding risk procedures below are in reference to pts on . Does anyone know what is the washout period for coming off clopidogrel? Onset of effects is about two hours and lasts for five days. It takes 5.5 x half-life of a medicine for it to be out of one's system, therefore Plavix should be eliminated from your system in 5.5 x … clopidogrel Plavix Over a 6 week period participants will be given: 75 mg of clopidogrel for 8 days, at least 1 week washout, 150 mg of clopidogrel for eight days, at least 1 week washout… Price MJ, Walder JS, Baker BA, Heiselman DE, Jakubowski JA, Logan DK, Winters KJ, Li W, Angiolillo DJ. However, when patients with >5 days of washout were compared with patients who underwent CABG within 5 days of clopidogrel treatment, the patients with the shorter washout period were almost twice as likely to require reoperation and were significantly more likely to experience major bleeding or a combined endpoint that included mortality, myocardial infarction, stroke, and … 1. Clopidogrel 75 mg tablet administered once daily for 7 days. U.S. Department of Health and Human Services, The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. That's just two different ways of saying the same thing! Starting on a cardiac floor, was wondering what a plavix washout is. Hi. Guidance on the emergent reversal of oral thrombin and factor Xa inhibitors. Review side effects, off-label uses, drug interactions, dosage, and pregnancy safety information. During each phase, plasma concentrations of parent drug and active and inactive metabolites were measured along with impedance platelet aggregometry in response to adenosine diphosphate (ADP). For example: Motrin, Advil, Ibuprofen • Do not take Vitamin E products 7 days before the biopsy. Plan Your Ride Select Ride Date. Stop taking Plavix at the designated time (again, at least five days before surgery). This test measures the extent of platelet aggregation in the presence of P2Y12 inhibitor drugs such as clopidogrel (Plavix), prasugrel (Effient), ticagrelor (Brilinta) and ticlopidine (Ticlid). The results from the present meta-analysis suggest that patients who present with ACS should be treated with dual antiplatelet therapy, including clopidogrel. Active treatment will be followed by a 1-day to 12-day Washout period depending on the time to reach both of the exit criteria. But plavix zdravilo not the spirits of one facing a cold, apparently blanket-less night in an unheated hostel. Epub 2011 Sep 30. Thanks everyone! The results are … Answered by : ... A neurologist put me on clopidogrel a few weeks ago when he wasn t convinced I didn t have a mini stroke, even after MRI didn t show one. If confirmed, the … Plavix is an antiplatelet drug. Prasugrel 10mg tablet administered once daily for 7 days. Plavix has been evaluated for safety in more than 54,000 patients, including over 21,000 patients treated for one year or more. If you fall or hurt yourself, or … Discontinue clopidogrel 5-7 days prior to surgery. One study of 40 patients undergoing hip fracture surgery reported no difference in bleeding between patients on Plavix versus those who were not. I had a heart attack October 2007. Common side effects include headache, nausea, easy … This poses a challenge because being on Plavix is associated with higher risks of perioperative bleeding, but stopping Plavix puts patients at increased risk for in-stent thrombosis. allnurses.com, INC, 7900 International Drive #300, Bloomington MN 55425 However, interruption of therapy is potentially hazardous in patients with recent stent placement. HOW BRILINTA HELPS PROTECT YOU FROM HAVING ANOTHER HEART ATTACK. Conventional clopidogrel desensitization protocols, while successful in most patients, employ a washout period off medication to enable accurate detection of a reaction during the desensitization. Plavix does not work for those who have poor cyp2C19 is defective and it is due to SNPS this goes under gene polymorphism. Clopidogrel (Plavix, generic) may be used in place of aspirin for people who have narrowing of the coronary arteries or who have had a stent inserted. ... [Designated as safety issue: No]On the first day of the Washout Period (Visit 3), the blood draw for platelet function testing was obtained 24 hours (+/- 6 hours) after the last dose of study medication. Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01014624. Plavix … Subjects with a competent mental condition to provide written informed consent before entering the study. Clopidogrel is cheap and the preferred P2Y12 receptor blocker of the two. I work in CICU. On the first day of the Washout Period (Visit 3), the blood draw for platelet function testing was obtained 24 hours (+/- 6 hours) after the last dose of study medication. [ Time Frame: up to 12 days after last dose ], Day at Which 50%, 75%, and 90% of Subjects Returned to Baseline Platelet Function Based on the Primary Definition of Return to Baseline Using the Responder Population. Keywords provided by Daiichi Sankyo, Inc.: Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number): Why Should I Register and Submit Results? If you extrapolate to the 1.24 million UA/NSTEMI patients admitted to U.S. hospitals each year, “Plavix washout” would result in more than a million patient-days in hospitals — an enormous expense and inconvenience just to compensate for up-front loading. Treatment A consisted of 300 mg clopidogrel on day 1 and 75 mg clopidogrel on day 2. By using the site you agree to our Privacy, Cookies, and Terms of Service Policies. Get the latest research information from NIH: You have reached the maximum number of saved studies (100). [ Time Frame: up to 12 days after the last dose ], Male or female subjects >/= 18 years and <75 years of age, On aspirin therapy (81 mg to 325 mg daily) at the time of screening and able to maintain a consistent aspirin dosing regimen from the baseline visit through the final study visit. Plavix cost plavix side effects skin rashes • Side-effects may include, when to stop plavix before dental surgery but are not limited to, vomiting. Plavix side effects eyes Many times, if the patient is stable enough, the surgeons will wait for the effects of Plavix to wear off before the patient is considered ready for surgery. Following Visit 3, platelet function testing was performed during each visit of the Washout Period until the subject met the following exit criteria: (Baseline PRU-PRU) less than or equal to 60 units and (Baseline PRU-PRU)/(Baseline PRU) less than or equal to 20%. The 14 clopidogrel responders were randomly assigned to one of the following three treatments with a washout phase of about 14 days between treatments (Figure 1). JACC Cardiovasc Interv 2008; 1:612. Another patient in the same cardiac rehab class was the same - Plavix for 3 months, and yet another is still taking Plavix and has been told to continue taking it. Local ocular solutions or ointments have nominal shrewdness, plavix and alcohol use express dilution, and rend washout and rely practically on patient compliance to adminis- … what is the target? This list is not complete. Plavix is given to reduce the risk of heart attack, unstable angina, stroke, and cardiovascular death in patients ... After a washout period, subjects were crossed over to the alternate treatment. [ Time Frame: up to 12 days after the last dose ], Percentage of Platelet Inhibition on Washout Day 1 [ Time Frame: Washout Day 1 ], Time to Return to Baseline PRU for the Primary Population Using the Primary Definition of Return to Baseline in Relation to the Inhibition of Platelet Aggregation 24 Hours Following the Last Maintenance Dose. Context Thienopyridines are among the most widely prescribed medications, but their use can be complicated by the unanticipated need for surgery. All participants received loading and maintenance doses of both drugs, in a crossover manner, separated by a 2-week washout period. Thanks! Plavix is given to reduce the risk of heart attack, unstable angina, stroke, and cardiovascular death in patients with cardiovascular disease. any other medicines to treat or prevent blood clots - Plavix, Pradaxa, Xarelto, Ticlid, and others. Two stents fitted RCA for 100% blockage. Subjects with significant hypertension (systolic blood pressure >180 mmHg or diastolic blood pressure >110 mmHg) at either the time of screening or baseline assessment. The "washout" of volatile anesthetics occurs from turning off the vaporizer, turning up the oxygen flow thereby "washing out" the gas. The frequency categories plavix vs pradaxa used are. (opens new window) Kaatz S, Kouides PA, Garcia DA, Spyropolous AC, Crowther M, Douketis JD, Chan AK, James A, Moll S, Ortel TL, Van Cott EM, Ansell J. Inhibition of platelet function has become a primary therapeutic goal. Following Visit 3, platelet function testing ws performed during each visit of the Washout Period until the subject met the following exit criteria: (Baseline PRU-PRU) less than or equal to 60 units and (Baseline PRU-PRU)/Baseline PRU less than or equal to 20%. Group Plavix® and then Clopidogrel: Patients will receive a unique dose of 75mg (a tablet) of Plavix® by oral route between 8:00 and 9:00am. This information is for guidance only. It helps keep blood flowing smoothly in your body. Effient is a very expensive brand-name-only option, so if for some reason you have a problem taking clopidogrel you can use Effient. allnurses is a Nursing Career, Support, and News Site. METHODS: This prospective study investigated whether there is any significant difference in the antiplatelet effect of Plavix versus generic clopidogrel hydrochloride in healthy male volunteers. Where to buy permethrin 10 The 14-year-old was found hanged after being bullied on the social networking site. However, patients who underwent CABG < 5 days after the last dose of clopidogrel had a significantly greater incidence of reoperation, major bleeding, and combined adverse outcomes than those who had had a washout period >5 days. BRILINTA is a medication for people who have had a heart attack, and it’s been proven to significantly lower the risk of having another heart attack.Watch the video below to see how BRILINTA + aspirin helps stop platelets from reacting and forming a new clot that could cause another heart attack. Kadapa rims hospital images but while the slip dress was a major look in the grunge era of the 90s - think courtney love, smudged eyeliner, worn over jeans or ripped tights but always with a pair of dr marten boots -the louis vuitton take is … Following Visit 3, platelet function testing was performed during each visit of the Washout Period until the subject met the following exit criteria: (Baseline PRU-PRU) less than or equal to 60 units and (Baseline PRU-PRU)/(Baseline PRU) less than or equal to 20%. The clinically important adverse reactions observed in trials comparing Plavix plus aspirin to placebo plus aspirin and trials comparing Plavix alone to … The gas doesn't get metabolized like a drug like Plavix. Study results announced at the American College of Cardiology (ACC) 2011. I know the actual dosage takes 33 hours to clear out and 7 days for the platelets to be re-activated. Time to return to baseline PRU (<= 60 units of baseline) dependent upon baseline PRU and platelet % inhibition on Washout Period Day 1 but independent of treatment. Prior history of abnormal bleeding tendency (ie, prolonged bleeding on dental extraction, tonsillectomy, or previous surgical procedure), Known prior history of thrombocytopenia (platelet count < 100,000/mm³) or thrombocytosis (platelet count > 500,000/mm³) or recent history (within six months) of hemoglobin < 10 mg/dL, Clinically significant out of range values for prothrombin time, activated partial thromboplastin time (aPTT), platelet count, or hemoglobin at screening, in the investigator's opinion, History of major surgery, severe trauma, fracture, or organ biopsy within 3 months prior to enrollment, Subjects taking prasugrel, clopidogrel, ticlopidine, cilostazol, dipyridamole, warfarin, heparin, direct thrombin inhibitors, or glycoprotein IIB/IIIa inhibitors =10 days prior to screening or during study participation, The use (or planned use) of fibrinolytic agents within 30 days before screening or during study participation, Subjects receiving treatment with nonsteroidal anti-inflammatory drugs (NSAIDs) or cyclooxygenase-2 (COX-2) inhibitors exceeding 3 doses per week, Subjects receiving proton pump inhibitors (PPIs), eg, (lansoprazole, esomeprazole, omeprazole, pantoprazole, or rabeprazole) =10 days prior to screening or during study participation, Investigator site personnel directly affiliated with the study or immediate family of investigator site personnel directly affiliated with the study. with a washout phase of about 14 days between treatments (Figure 1). GPIIb/IIIa Bridge when Holding an Oral Antiplatelet Agent After placement of a coronary drug-eluting stent (DES), patients are required to be on a P2Y12 inhibitor The "washout" of volatile anesthetics occurs from turning off the vaporizer, turning up the oxygen flow thereby "washing out" the gas. L between pre- and post-imaging. Following this I was on Plavix for 3 months. 75 mg; 300 mg Official Answer. Previous history of duodenal ulcer is acceptable but must have been successfully surgically or medically treated with no further evidence of disease in the past 6 months (from screening). After a single, oral dose of 75 mg, Plavix (clopidogrel) has a half-life of approximately 6 hours. Percutaneous Endoscopic Gastrostomy (PEG) is a commonly performed procedure amongst hospitalized patients. Subjects who do not have contraindications for a thienopyridine (ie, prasugrel, clopidogrel or ticlopidine), and have a history of stable atherosclerosis represented by Coronary Artery disease, defined as any of the following: Female subjects who meet one of the following: Prior/Concomitant Therapy Exclusion Criteria: To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. After a single, oral dose of 75 mg, Plavix (clopidogrel) has a half-life of approximately 6 hours. Treatment B consisted of a single dose of 15 mg rivaroxaban. Clopidogrel (Plavix) (Medical Encyclopedia) How to give a heparin shot (Medical Encyclopedia) Taking warfarin (Coumadin) (Medical Encyclopedia) Code Classification. J Am Coll Cardiol. It's all dependent on what the drug's MOA is, their half lives, the relative risk of the procedure, and surgeon preference. Any known contraindication to treatment with an anticoagulant or antiplatelet agent, Prior history or clinical suspicion of cerebral vascular malformations, intracranial tumor, transient ischemic attack (TIA), or stroke, or recent history (within 3 months) of head trauma, Prior history or presence of significant bleeding disorders (eg, hematemesis, melena, severe or recurrent epistaxis, hemoptysis, hematuria, or intraocular bleeding). 2012;23(3):167-76. doi: 10.3109/09537104.2011.610475. Immediate family is defined as a spouse, parent, child, or sibling, whether biological or legally adopted, Currently enrolled in, or discontinued within the last 30 days prior to baseline from, a clinical study involving an off-label use of an investigational drug or device, or concurrently enrolled in a non-observational clinical study or any other type of medical research judged not to be scientifically or medically compatible with this study, Have previously completed or withdrawn from this study, Women who are known to be pregnant and/or who receive a positive serum pregnancy test result, who have given birth within the past 90 days, and/or who are breastfeeding, Results of clinical laboratory tests at the time of screening that are judged to be clinically significant for the subject, as determined by the investigator, Known allergies or intolerance to aspirin and/or thienopyridines (prasugrel, clopidogrel, or ticlopidine), Evidence of significant active neuropsychiatric disease, alcohol abuse or drug abuse, in the investigator's opinion, Evidence of active hepatic disease, or any of the following; positive human immunodeficiency virus (HIV) antibodies, positive hepatitis C antibody, positive hepatitis B surface antigen; serum alanine transaminase (ALT), aspartate transaminase (AST), or gamma-glutamyltransferase (GGT) >/= 3 times the upper limit of normal (ULN) laboratory reference range; or bilirubin >/= 2 times the ULN of laboratory reference range at screening, Subjects who are unreliable and unwilling to make themselves available for the duration of the study and who will not abide by the research unit policy and procedure and study restrictions, Subjects who have had an angiogram
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